Oral desensitization to milk: how to choose the starting dose!

نویسندگان

  • Francesca Mori
  • Neri Pucci
  • Maria Elisabetta Rossi
  • Maurizio de Martino
  • Chiara Azzari
  • Elio Novembre
چکیده

A renewed interest in oral desensitization as treatment for food allergy has been observed in the last few years. We studied a novel method based on the end point skin prick test procedure to establish the starting dose for oral desensitization in a group of 30 children highly allergic to milk. The results (in terms of reactions to the first dose administered) were compared with a group of 20 children allergic to milk as well. Such control group started to swallow the same dose of 0.015 mg/ml of milk. None reacted to the first dose when administered according to the end point skin prick test. On the other side, ten out of 20 children (50%) from the control group showed mild allergic reactions to the first dose of milk. In conclusion the end point skin prick test procedure results safe and easy to be performed in each single child in order to find out the starting dose for oral desensitization to milk, also by taking into account the individual variability.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

حساسیت‌زدایی خوراکی در کودکان مبتلا به آلرژی به شیر گاو: کارآزمایی بالینی آینده‌نگر

Background: Cow's milk protein allergy (CMPA) is the most common food allergy during the first year of life. Strict avoidance of specific foods is the only accepted treatment for food-induced allergic reactions. This is often an unrealistic therapeutic option, since cow's milk is a basic food that is extensively used in infant formula. The recent preliminary experience of oral desensitization t...

متن کامل

Role of basophil activation test for monitoring the immunological changes during desnsitization to cow’s milk: a case report

The basophil activation test (BAT) has proven to be a useful tool for the diagnosis of IgE-mediated food allergy and the evaluation of clinical tolerance in food allergic patients. Until now, successful oral desensitization to food allergen has been correlated with changes in cytokine production (IL-4 and INF-g) and allergenspecific IgE and IgG4 antibodies. We report a case of a 12-year-old mal...

متن کامل

Whole food or processed food or mutated recombinant protein?

Diverse therapeutic strategies for food allergy are under investigation including food allergen-specific and nonspecific approaches. Allergen-specific approaches include immunotherapy with native food allergens, immunotherapy with mutated recombinant allergens, and diets containing extensively heated milk or egg. Native allergen immunotherapy can be administered via oral, sublingual, subcutaneo...

متن کامل

A new protocol for specific oral tolerance induction in children with IgE-mediated cow's milk allergy.

IgE-mediated cow's milk allergy (CMA) is a heavy burden for patients, particularly for children and their families. Allergen avoidance represents the only therapeutic option, but oral desensitization protocols have been suggested. Because of the long duration and complexity of these protocols we examined the feasibility of an oral tolerance induction protocol using a weekly up-dosing schedule. ...

متن کامل

Efficacy of high-dose oral erythromycin on enhancement of feeding tolerance in premature neonates

Objective: Most   neonates admitted to neonatal wards do not tolerate sufficient milk.  Recently the effect of erythromycin on increasing feeding tolerance in neonates has been studied. In this study the effectiveness of oral, high dose Erythromycin a prokinetic agent was used to enhance feeding tolerance in these neonates.  Methods: This prospective randomized controlled clinical trial was con...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 21  شماره 

صفحات  -

تاریخ انتشار 2010